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CANC-012A

Name: CANC-012A
The alias: 
Sequence of single letter abbreviation:
A basic description:This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with dimethylation at Lys372 and additional KGW residues on its N-terminus. Methylation at Lys372 activates p53 and induces upregulation of target gene p21. Methylation at Lys372 also inhibits Lys370 methylation by interfering with Smyd2, a lysine methyltransferase, and p53 interaction. Lys 370 methylation reduces p53 transcriptional targets.
solubility:
The molecular weight: 3467
Chemical formula: 
The purity: > 95%
Storage conditions: Store at -20℃. Keep tightly closed. Store in a cool dry place.
Annotation:
Reference:Huang, J. et al. Nature 440, 629 (2006)
The C-terminal:
The N-terminal: 
Chemical bridge: 

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